Direct Mechano-Stress Sensitivity of TRPM7 Channel
نویسندگان
چکیده
منابع مشابه
The Pathophysiologic Roles of TRPM7 Channel
Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg(2+) and Ca(2+), and its channel activity is negatively regulated by free Mg(2+) and Mg-complexed nucleotides. Recent s...
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Evidences showed that physical forces, as passive stretching or active contraction, may counteract various kinds of skeletal muscle atrophy due, for instance, to muscle immobilization, pathophysiology or denervation. In accord, active muscle contraction induced by functional electrical stimulation resulted helpful to reduce the muscle atrophic state in denervated man. Moreover, there are eviden...
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TRPM7 is a member of the Transient-Receptor-Potential Melastatin ion channel family. TRPM7 is a unique fusion protein of an ion channel and an α-kinase. Although mammalian TRPM7 is well characterized biophysically and its pivotal role in cancer, ischemia and cardiovascular disease is becoming increasingly evident, the study of TRPM7 in mouse models has been hampered by embryonic lethality of tr...
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Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a bi-functional protein comprising a TRP ion channel segment linked to an α-type protein kinase domain. Genetic inactivation of TRPM7 revealed its central role in magnesium metabolism, cell motility, proliferation and differentiation. TRPM7 is associated with anoxic neuronal death, cardiac fibrosis and tumor progression...
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Sick sinus syndrome and atrioventricular block are common clinical problems, often necessitating permanent pacemaker placement, yet the pathophysiology of these conditions remains poorly understood. Here we show that Transient Receptor Potential Melastatin 7 (TRPM7), a divalent-permeant channel-kinase of unknown function, is highly expressed in embryonic myocardium and sinoatrial node (SAN) and...
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ژورنال
عنوان ژورنال: Cellular Physiology and Biochemistry
سال: 2007
ISSN: 1015-8987,1421-9778
DOI: 10.1159/000099187